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Ticker: CVKD (NASDAQ)

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💔 Heart Disease: America’s Most Expensive Killer

And the Public Company Quietly Developing a Potential Game-Changer

Every 36 seconds, someone in the United States dies from heart disease. That adds up to over 2,300 deaths every single day. More than 121 million Americans are living with cardiovascular disease. Annual direct medical costs have surpassed $200 billion, burdening patients, families, and the healthcare system. Yet the most widely used blood thinner, Warfarin, has remained unchanged for more than 60 years.

The Reality of Today’s Blood Thinners

Warfarin has been prescribed for decades to reduce the risk of stroke, clotting, and other cardiovascular complications. But its limitations are widely known:

  • Requires frequent blood testing and dose adjustments
  • Interacts with common foods (especially those rich in Vitamin K)
  • Has dangerous drug-to-drug interactions
  • Carries a high risk of internal bleeding, including GI bleeds
  • Complicates treatment in elderly and kidney-impaired patients

Patients don’t choose Warfarin because it’s ideal — they choose it because it’s the only FDA-approved option in many cases.

The Unmet Medical Need

Patients with implanted cardiac devices like Left Ventricular Assist Devices (LVADs) are particularly vulnerable. They require lifelong anticoagulation therapy — yet Warfarin puts them at high risk of bleeding, especially when combined with chronic kidney disease.

This population has no oral anticoagulant currently approved specifically for their needs. The medical gap is urgent and growing.

Introducing Cadrenal Therapeutics (CVKD)

Cadrenal Therapeutics (NASDAQ: CVKD) is a clinical-stage biopharmaceutical company developing Tecarfarin, a novel oral blood thinner designed to address the limitations of Warfarin.

Tecarfarin is a Vitamin K antagonist (VKA) like Warfarin — but with a key distinction: it’s metabolized by carboxyl esterase, not the liver’s cytochrome P450 system. This alternative metabolic pathway is being explored for its potential to offer greater stability, fewer interactions, and better suitability for patients with kidney or liver issues.

Tecarfarin’s Potential Advantages

  • Fewer food and drug interactions
  • Not dependent on kidney or liver function
  • More consistent therapeutic levels
  • Lower bleeding risk profile (pending trial outcomes)
  • Being developed for high-risk patients, including those with LVADs

Tecarfarin is being developed to potentially deliver the benefits of anticoagulation therapy with fewer of the complications commonly associated with older treatments like Warfarin.

Latest Developments: Manufacturing & Trial Readiness

On May 15, 2025, Cadrenal Therapeutics (CVKD) announced the successful completion of the technical transfer and U.S.-based manufacturing of Tecarfarin’s active pharmaceutical ingredient (API). This milestone is intended to strengthen the company’s supply chain and support readiness for upcoming pivotal trials.

Read the full press release on BusinessWire

The company is preparing Tecarfarin for a Phase 3 clinical study, initially targeting two high-risk patient groups:

  • Patients with implanted cardiac devices (LVADs)
  • Patients with end-stage kidney disease and atrial fibrillation

If approved, Tecarfarin could become the first oral anticoagulant specifically indicated for these populations.

Analyst Coverage: “Buy” Rating Reaffirmed

In May 2025, H.C. Wainwright & Co. reiterated a Buy rating on CVKD, issuing a price target of $32, citing Tecarfarin’s differentiated profile, market potential, and advancing clinical pipeline.

“We believe CVKD’s progress on manufacturing and trial planning, combined with Tecarfarin’s unique mechanism, supports a favorable risk-reward ratio for long-term investors.” — H.C. Wainwright Equity Research (May 2025)

📄 Read the full analyst coverage on GuruFocus

Why Investors Are Watching CVKD

Strategic FactorWhy It Matters
FDA Orphan Drug StatusCreates exclusive market rights and accelerates the process
Large, underserved market High-risk patients need alternatives now
Platform potentialCould extend beyond LVADs into other cardiac segments
First-mover advantage No oral blood thinner is currently approved for LVAD patients
Public listingTicker: CVKD (accessible on the open market)

CVKD is positioned at the intersection of medical innovation and patient need. For investors seeking early-stage exposure to potential breakthroughs in cardiovascular care, this is a company to watch closely.

About the Company

  • Company: Cadrenal Therapeutics, Inc.
  • Ticker: CVKD
  • Exchange: NASDAQ
  • Sector: Biopharmaceuticals
  • Focus: Cardiovascular therapies, next-generation anticoagulation
  • Website: www.cadrenal.com

Sponsored Content Disclosure: This content is part of a paid awareness campaign. Please read the full disclaimer below.

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STOCK INFORMATION

neov

Cadrenal Therapeutics, Inc.

CVKD neov Nasdaq Stock Market

February 26

Upcoming Earnings

EPS

Market cap

USD (%)

Market Closed (as of 06:29 GMT+5:30)

Add CVKD to your watchlist today

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